HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this link to a friend Similar articles in this journal Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kennedy, P. G. E. Search for Related Content PubMed Articles by Kennedy, P. G. E.

Sleeping sickness – human African trypanosomiasis

Burton Professor of Neurology, Head of University Department of Neurology, Division of Clinical Neurosciences, University of Glasgow, Institute of Neurological Sciences, Glasgow, UK; E-mail: P.G.Kennedy{at}clinmed.gla.ac.uk

EXTRACT

INTRODUCTION

One of the great advantages of working with veterinary colleagues is the insight they often bring to the pathogenesis of human disease through their studies of natural animal diseases and animal models. In 1988 Professor Max Murray of the University of Glasgow Veterinary School introduced me to the problem of African trypanosomiasis in animals, its close relationship to its human counterpart that is known as sleeping sickness, and the unsolved problems of neurological involvement in that condition. We have now been investigating the neuropathogenesis of human African trypanosomiasis (HAT) in the laboratory and the African field for the last 16 years (Fig. 1). Neurologists will realize of course that HAT is not to be confused with the other ‘sleeping sickness’ known as encephalitis lethargica, famous for the pandemic during the first quarter of the 20th century, and which still occurs sporadically. While the cause of the latter disease has ...

[PDF of this article]