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A young man with rapidly progressive multifocal disease affecting the white matter

¹ Clinical Director, MDC Muscle & Nerve Centre, Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
² Professor of Clinical Neuropathology, Division of Pathology, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK
³ Specialist Registrar in Neurology, Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK

Correspondence to:
Correspondence to:
Dr D J Simpson
Department of Clinical Neurosciences, Western General Hospital, Edinburgh EH4 2XU, UK; david.simpson@luht.scot.nhs.uk

The first 150 words of the full text of this article appear below.

A 32-year-old right-handed man presented with a two day history of gradual weakness and clumsiness of the right hand, followed by sudden weakness of the right leg. His partner described a transient episode of slurred speech accompanied by right-sided facial droop on the day before admission, of which the patient had been unaware. There was no history of any preceding infectious or other illness, and no fever or headache at presentation. Six months previously he had had a number of brief episodes of "twitching" of the right leg during which he had needed to lean on walls or furniture for support. One month before admission he had developed similar episodes involving the left hand. He had a background history of type 1 diabetes mellitus. His glycaemic control was said to have been poor in the past, and he had had an episode of diabetic ketoacidosis in 1993. Blood pressure (BP) . . . [Full text of this article]

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