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CARPHOLOGY BY Rajendra

Aspirin and cognition

Long-term use of low dose aspirin does not protect against cognitive decline in healthy and mostly white women aged 65 or more. This is the finding of a randomised, double-blind, placebo-controlled trial in which low dose aspirin was given to a subset of 6377 women participating in the Women’s health study. At the initial assessment (mean 5.6 years after randomisation) cognitive performance in the aspirin group was similar to that of the placebo group (mean difference in global score –0.01, 95% CI –0.04 to 0.02). According to the authors this trial does not support previous laboratory and epidemiological evidence that suggested that aspirin and other anti-inflammatory drugs may be protective against dementia.

BMJ 2007;334:987.[Abstract/Free Full Text]

Herpes simplex encephalitis

Herpes simplex encephalitis continues to be associated with poor long-term outcomes despite treatment with intravenous aciclovir. This is the finding of a simple prospective register-based observational study of children done in . . . [Full text of this article]