A difficult case
Anti-Hu syndrome: a rare presentation and a very difficult decision
1 Department of Neurology, Aberdeen Royal Infirmary, NHS Grampian University Hospitals NHS Trust, Aberdeen, UK
2 Department of Anaesthetics, Aberdeen Royal Infirmary, NHS Grampian University Hospitals NHS Trust, Aberdeen, UK
Correspondence to:
Correspondence to:
Dr U Schulz
Department of Neurology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK; ursula.schulz@nhs.net
| The first 150 words of the full text of this article appear below. |
Anti-Hu syndrome is the most commonly recognised paraneoplastic condition, typically characterised by a sensory neuropathy or a cerebellar syndrome.1,2 We have recently looked after a patient who—unusually—presented with a rapidly progressive motor syndrome, who was both a diagnostic and an ethical challenge.
A 64-year-old lady presented with a three-week history of painless increasing arm weakness, breathlessness and difficulty walking. By the time she was admitted to hospital her symptoms had deteriorated to the extent that she was unable to lift her arms to feed or to dress herself. She had also started to wear a soft collar because she was unable to hold her head up. Her illness had been preceded by a one-week prodrome of general fatigue and malaise. She had previously been well with no significant past history. She was a longstanding smoker of 50 pack-years.
On examination she looked unwell and was breathless at rest with paradoxical
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Practical Neurology 2007 7: 279.
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