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Carphology by A Fo Ben

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MS: the old…

Sometimes the most acute observation is possible when you encounter it fresh—as an outsider. When Geoffrey Dean (1918–2009) arrived in South Africa in 1947, he noticed the marked variation in multiple sclerosis prevalence among the different ethnic groups. With John Kurtzke, he established that immigration before aged 15 years old was associated with a lower risk of multiple sclerosis in immigrants from Northern Europe. He was also a vocal antiapartheid critic—he was arrested for this—and published his last paper in Neurology when aged 89; he died aged 90.

…and the new

New England Journal of Medicine has treated us to three quality trials of novel MS agents. Oral fingolimod (preventing lymphocyte egress from lymph nodes) reduced both …

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