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Test? match; special

When designing a screening test for a very rare disorder, it needs to be very specific (no false positives). When the condition is as emotive as Creutzfeldt–Jakob disease (CJD), the discovery of the real time quaking induced conversion (RT-QUIC) assay could be an important breakthrough. This CSF test could replace the existing biomarkers and rival brain biopsy as a gold standard in diagnosis. It identified sporadic and iatrogenic CJD correctly, but the real test will come in clinical practice.

Evidence driving practice

Driving law currently varies state by state in the USA and country by country in Europe. A move to harmonise European driving law following seizures motivated Tony Marson et al to assess whether European recommendations were correctly based. A re-analysis of the Multicentre Study …

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