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Cerebral vasospasm and anterior circulation stroke secondary to an exacerbation of hereditary corproporphyria
  1. Stephen Mullin1,
  2. Andrew Platts2,
  3. Kashmir Randhawa3,
  4. Paul Watts1
  1. 1Department of Clinical Neurosciences, Royal Free Hampstead NHS Trust, London, UK
  2. 2Department of Neuroradiology, Royal Free Hampstead NHS Trust, London, UK
  3. 3North West Thames Regional Genetics Centre, Northwick Park Hospital, London, UK
  1. Correspondence to Dr Stephen Mullin, Department of Clinical Neurosciences, Royal Free Hampstead NHS Trust, Pond Street, London NW3 2GQ, UK; s.mullin{at}nhs.net

Abstract

Acute porphyria, though rare, has well-known neurological sequelae. Vasospasm rarely complicates exacerbations of acute intermittent porphyria, but has not been previously reported in hereditary coproporphyria. We describe a porphyric crisis in a woman with previously undiagnosed hereditary coproporphyria (triggered by rifampicin), leading to vasospasm and stroke.

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