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Carphology by A Fo Ben

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The solution is crystal clear

If you only watch one video of a transparent mouse brain this year—make it this one. www.youtube.com/watch?v=c-NMfp13Uug. The study of brain structure and development focuses on microscopic change. Conclusions regarding pathways and connectivity are limited when looking at wafer-thin dissected tissue. Neuroanatomical research would be simpler if much of the brain was see-through. Chung et al of Stanford University describe a method of creating a hybrid mesh and clearing opaque fats in biological tissue. This ensures that the structure is kept intact but that the tissue is transparent. They name this revolutionary method CLARITY. In addition, the technique allows you to label neurotransmitters and genes of interest and trace a single …

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