A protocol for the inhospital emergency drug management of convulsive status epilepticus in adults
- 1Pharmacy Department, Kings College Hospital NHS Foundation Trust, London, UK
- 2Department of Neuroscience Intensive Care, Kings College Hospital NHS Foundation Trust, London, UK
- 3Department of Neurology, Paracelsus Medical University, Salzburg, Austria
- 4Department of Neurology, Kings College Hospital NHS Foundation Trust, London, UK
- Correspondence to Shelley Jones, Clinical Pharmacy Teamleader, Neurosciences, Pharmacy Department, Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK;
There are many options for treating convulsive status epilepticus but one thing is clear: success is closely associated with timely intervention and adherence to a treatment protocol.1 Delayed intervention leads to treatment resistance and refractory status. There is little evidence from randomised controlled trials, especially for agents used after benzodiazepines.2 Therefore, for now, the choices are mostly based not on Class 1 evidence but on accumulated and published experience.
Management protocols are mandatory if patients with status epilepticus are to receive prompt and appropriate treatment. Yet many hospitals do not have these or do not review them regularly. This protocol is adapted from that of King's College Hospital, London, UK, and is in line with the European consensus workshop.2 We aim to provide sufficient detail to satisfy the treating …