Article Text

PDF
Giant cell myositis responsive to combined corticosteroids and immunoglobulin
  1. A Shah1,
  2. A Pace2,
  3. D Hilton3,
  4. E Househam1,
  5. S Weatherby1
  1. 1Department of Neurology, Derriford Hospital, Plymouth Hospitals NHS Trust, Plymouth, UK
  2. 2Department of Neurology, Greater Manchester Neurosciences Centre, Salford Royal NHS Foundation Trust, Manchester, UK
  3. 3Department of Neuropathology, Derriford Hospital, Plymouth Hospitals NHS Trust, Plymouth, UK
  1. Correspondence to Dr Alexander Shah, Department of Neurology, Derriford Hospital, Plymouth Hospitals NHS Trust, Plymouth PL68DH, UK; alex.shah{at}doctors.org.uk

Abstract

A 70-year-old man presented with respiratory distress and proximal muscle weakness shortly after biopsy of a left forearm mass. The biopsy showed giant cell myositis, and serological investigations identified a grossly elevated serum creatine kinase level, suggesting skeletal muscle damage. Serum troponin T was also high, but troponin I was normal. Serum antiacetylcholine receptor antibodies were positive, and imaging showed a thymoma. He recovered well following intravenous immunoglobulin and corticosteroids, and later underwent thymectomy. He is currently in sustained remission, with no clinically detectable myasthenia, but subsequently, developed hypogammaglobulinaemia. Neurologists should remember giant cell myositis/myocarditis can occur in patients who have myasthenia gravis with thymoma, as it is potentially fatal, but may respond to immunosuppression.

  • MUSCLE DISEASE
  • MYASTHENIA
  • NEUROPATHOLOGY, MUSCLE
  • NEUROIMMUNOLOGY
  • CARDIOLOGY

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.