Article Text
A difficult case
Cryptococcal meningitis in apparently immunocompetent patients: association with idiopathic CD4+ lymphopenia
Abstract
We present two cases of cryptococcal meningitis in people subsequently diagnosed with idiopathic CD4+ lymphopenia. Both presented with new onset headaches without sinister features and were sent home on multiple occasions from emergency departments. Cryptococcal meningitis in HIV-negative patients poses major diagnostic and management problems; the associated mortality is 9%–27%. We suggest performing blood and cerebrospinal fluid cryptococcal antigen tests in all people with lymphocytic meningitis.
- infectious diseases
- meningitis
- lymphopaenia
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