Creutzfeldt-Jakob Disease (CJD) is a rare fatal neurological disease, with four distinct forms. Sporadic CJD (sCJD) is the most common and is characterized by a rapidly progressive dementing illness, associated with EEG abnormalities and CSF protein changes (14-3-3 protein). In addition, there are characteristic magnetic resonance imaging (MRI) changes, consisting of basal ganglia (putamen and caudate head) hyperintensity. Although these abnormal appearances overlap with other diseases, their presence is diagnostically useful. In variant CJD (vCJD), the form of CJD associated with bovine spongiform encephalopathy (BSE), the pulvinar sign – a characteristic appearance of bilateral hyperintensity in the posterior nuclei of the thalamus – is highly specific for the diagnosis of variant CJD in the appropriate clinical context. This article reviews these and other MRI appearances of CJD.
The transmissible spongiform encephalopathies (TSE) are a group of diseases affecting man and other animals, characterized by a fatal progressive neurological illness, characteristic
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.