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Neuro-Behçet’s Disease: a Practical Approach to Diagnosis and Treatment
  1. Gulsen Akman-Demir,
  2. Piraye Serdaroglu
  1. Istanbul University, Istanbul Faculty of Medicine, Department of Neurology, Çapa 34390, Istanbul, Turkey, e-mail: gdemir{at}turk.net

    Abstract

    BACKGROUND

    Behçet’s disease is a recurrent systemic inflammatory disorder of unknown aetiology. It was first described in 1937 as the triad of recurrent oral aphthous ulcers, genital ulceration and uveitis (Behçet 1937). Males are more commonly affected than females and the onset is usually in the third decade. Criteria established in 1990 by the International Study Group for Behçet’s Disease are now used for making the diagnosis (International Study Group for Behçet’s Disease 1990) (Table 1). But, as well as those cited in these criteria, many other organs and systems may be involved in Behçet’s disease, such as the vascular system, mainly the veins and pulmonary arteries, gastrointestinal system, joints and nervous system (Inaba 1989).

    NEUROLOGICAL INVOLVEMENT

    Male predominance is more pronounced among patients with neurological involvement (about 3 or 4 males for every female), and this usually starts about 5 years after the onset of the more usual symptoms

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