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A matched cohort study in adolescents with meningococcal disease recruited at hospital admission finds that being a student, intimate kissing with multiple partners, a history of preceding illness, and preterm birth were all independently associated with higher risk of meningococcal disease. According to the authors altering personal behaviours could moderate the risk, but the development of better vaccines is the key priority.
How safe is nicotine replacement therapy in patients with pre-existing cardiovascular disease? A simple observational study from a general practice database in over 33,000 individuals (of whom 861 had had a myocardial infarct and 506 a stroke) looks at the relative incidence of myocardial infarction and stroke in four 14 day periods before and after the first prescription for nicotine replacement therapy. Overall the risk of myocardial infarction, stroke, or death did not increase in the 56 days after the first prescription. However, the …
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