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CARPHOLOGY by Rajendra

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Multiple sclerosis in children

What is the natural history of multiple sclerosis which begins in childhood? Scientists used data from 13 adult neurology departments affiliated to the European Database for Multiple Sclerosis network to identify nearly 400 patients whose disease began at 16 years of age or younger. They compared these data with those obtained from 1775 patients whose disease began after the age of 16 years. They found that those with childhood onset disease were more likely to be female than male (2.8 vs 1.8), and to have an exacerbating-remitting initial course (98% vs 84%). They also took about 10 years longer to reach secondary progression and irreversible disability, but they reached these landmarks about 10 years younger. Thus patients with childhood-onset multiple sclerosis take longer to reach states of irreversible disability but do so at a younger age than patients with adult-onset disease.

Gene therapy for Parkinson’s disease

Gene therapy to the subthalamic nucleus is …

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