Article Text


Statistics from

Don’t you hate it when …

… you wait for a paper on genome wide association studies (GWAS) in schizophrenia and three come at once? Schizophrenia is perhaps 80% inherited but phenotyping is challenging and its major genes remain elusive.1 A pan-European study (n = 3322) of schizophrenia using GWAS reported important MHC region variants, strongly supporting a polygenic basis and explaining at least 30% of the liability. Intriguingly, schizophrenia’s genetic data are substantially shared with bipolar disorder.2 A meta-analysis of European ancestry people from three large datasets (8008 cases, 19 077 controls) identified an important linkage disequilibrium on chromosome 6p22.1 (p = 9.54×10−9); seven single nucleotide polymorphisms were significantly associated.3 The Wellcome Trust Case Control Consortium GWAS data for bipolar disorder were re-examined asking which of seven subtypes had the most independent associations. The answer: schizoaffective disorder, bipolar type.

1doi:10.1038/nature08192; 2doi:10.1038/nature08185; 3Br J Psychiatry 2009;195:23–9.

White spots in Icelandic migraine

In a prospective Icelandic cohort (n = 4689), 7.7% …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.