Coagulation of cerebrospinal fluid—the Nonne–Froin sign
- Niklas Mattsson1,
- Richard Montelius2,
- Anders Holtz3,
- Lisa Mouwitz4,
- Kaj Blennow1,
- Henrik Zetterberg1,5
- 1Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden
- 2Geriatric Clinic, Gävle County Hospital, Gavle, Sweden
- 3Department of Neuroscience, Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
- 4The Medical History Museum, Göteborg, Gothenburg, Sweden
- 5UCL Institute of Neurology, London, UK
- Correspondence to Dr Niklas Mattsson, Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital/Mölndal, University of Gothenburg, Mölndal 431 80, Sweden; niklas.mattsson{at}neuro.gu.se
A 60-year-old previously healthy woman sought medical attention at a memory clinic for subjective cognitive impairment. Neurological and cognitive testing was normal, except that she performed at the lower limit of normal in A Quick Test of Cognitive Speed (AQT) and Rey complex figure tests. MRI of the brain was normal. As a part of the investigation she underwent lumbar puncture, a routine procedure in memory investigations in Sweden.
The cerebrospinal fluid (CSF) was found to be yellow and viscous. The CSF flow through the lumbar …
