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Although neuropsychiatric symptoms are increasingly recognised in early established multiple sclerosis,1–3 it is unusual for patients to present with solitary cognitive or neuropsychiatric symptoms,4–12 including depressive symptoms4–7 ,10 ,11 and progressive cognitive decline.6 ,8 ,9 ,11 ,12 Here, we present a case of multiple sclerosis that presented as a relapsing amnestic syndrome with only very mild underlying cognitive changes.
A previously fit 76-year-old man reported a 2–3-h episode of agitation and confusion. During this, he became repetitive and obsessive and had no memory of this period afterwards. Following the event, his wife noticed that his memory was not quite as good as previously (particularly for people's names), but otherwise he had no residual cognitive or physical deficits.
His wife also reported that the year before …
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