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Adult-onset Alexander's disease mimicking degenerative disease
  1. Omar Ahmad,
  2. Dominic Brock Rowe
  1. Department of Macquarie Neurology, Macquarie University Hospital, Macquarie University, Sydney, New South Wales, Australia
  1. Correspondence to Dr Omar Ahmad, Department of Macquarie Neurology, 2 Technology Place, Macquarie University Hospital, Macquarie University, Sydney, NSW 2109, Australia; o_ahmad21{at}hotmail.com

Abstract

Adult-onset Alexander's disease is a rare leukodystrophy that can present later in life in a variety of ways, often mimicking more common neurodegenerative conditions. We present two cases with novel mutations, diagnosed from their characteristic MR scan findings. Even in much older people, clinicians should have a high clinical suspicion if there are typical imaging findings.

  • MRI
  • GENETICS

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