Article Text

other Versions

PDF
Clinical challenges in the diagnosis and management of postural tachycardia syndrome
  1. Pearl K Jones1,
  2. Brett H Shaw2,
  3. Satish R Raj3
  1. 1Department of Neurology, UT Health Science Center San Antonio, San Antonio, Texas, USA
  2. 2Cumming School of Medicine, University of Calgary, Calgary, Canada
  3. 3Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary
  1. Correspondence to Dr Pearl K Jones, University of Texas Health Science Center, 8300 Floyd Curl Drive, San Antonio, TX 78229-3900, USA; Jonesp3{at}uthscsa.edu

Abstract

Postural tachycardia syndrome (POTS) is a multifactorial clinical syndrome defined by an increase in heart rate of ≥30 bpm on standing from supine position (or ≥40 bpm in children). It is associated with symptoms of cerebral hypoperfusion that are worse when upright and improve when in supine position. Patients often have additional symptoms including severe fatigue and difficulty concentrating. There are several possible pathophysiologic mechanisms including hypovolaemia, small-fibre peripheral neuropathy and hyperadrenergic states. POTS can also be associated with several disorders including mastocytosis, Ehlers-Danlos syndrome (hypermobility type) and autoimmune disorders. The treatment is focused on symptom relief and not solely on reducing tachycardia. Given its varying presentations, it is important to employ a practical, mechanism-focused approach to the diagnosis and management of POTS.

  • postural tachycardia syndrome
  • POTS
  • tachycardia
  • orthostatic intolerance
  • AUTONOMIC

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • Editors' commentary
    Phil E M Smith Geraint N Fuller