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Leprosy in a patient infected with HIV
  1. Clare M Galtrey1,
  2. Hamid Modarres1,
  3. Zane Jaunmuktane2,
  4. Sebastian Brandner2,
  5. Alexander M Rossor3,
  6. Diana NJ Lockwood4,
  7. Mary M Reilly3,
  8. Hadi Manji3,
  9. Fred Schon1
  1. 1 St George’s University Hospitals, London, UK
  2. 2 Division of Neuropathology, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
  3. 3 Department of Molecular Neurosciences, MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, Queen Square, London, UK
  4. 4 London School of Hygiene & Tropical Medicine, London, UK
  1. Correspondence to Dr Clare M Galtrey, Department of Neurology, St George’s Hospital, Blackshaw Rd, London SW17 0QT, UK; clare.galtrey{at}gmail.com

Abstract

A 60-year-old Nigerian man, who had lived in Europe for 30 years but had returned home frequently, presented with right frontalis muscle weakness and right ulnar nerve palsy, without skin lesions. Neurophysiology showed a generalised neuropathy with demyelinating features. Blood tests were positive for HIV, with a normal CD4 count. There was nerve thickening both clinically and on MRI. Nerve biopsy showed chronic endoneuritis and perineuritis (indicating leprosy) without visible mycobacteria. His neuropathy continued to deteriorate (lepra reaction) before starting treatment with WHO multidrug therapy, highly active antiretroviral therapy and corticosteroids. There are 10 new cases of leprosy diagnosed annually in the UK. Coinfection with HIV is rare but paradoxically does not usually adversely affect the outcome of leprosy or change treatment. However, permanent nerve damage in leprosy is common despite optimal therapy. Leprosy should be considered in patients from endemic areas who present with mononeuritis multiplex.

  • Leprosy
  • HIV
  • Mononeuritis Multiplex

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    Phil E M Smith Geraint N Fuller