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Hypothyroid ataxia complicating monoclonal antibody therapy
  1. Abdul Badran1,
  2. Carla Moran2,
  3. Alasdair J Coles3
  1. 1University of Cambridge, Churchill College, Cambridge, UK
  2. 2Department of Clinical Neurosciences, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK
  3. 3Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK
  1. Correspondence to Abdul Badran, University of Cambridge, Churchill College, Storey's Way, Cambridge, CB3 0DS, UK; arb94{at}cam.ac.uk

Abstract

We present a case of cerebellar dysfunction due to severe hypothyroidism induced by pembrolizumab, a member of the ‘immune checkpoint inhibitor’ class of cancer immunotherapies. Thyroxine replacement completely resolved his symptoms and signs. We also discuss the neurological immune-related complications of checkpoint inhibitors.

  • neuroimmunology
  • cerebellar ataxia
  • neuroendocrinology

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Footnotes

  • Contributors AB drafted this case report. CM and AJC edited the report and contributed to the discussion.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed. This paper was reviewed by Marios Hadjivassiliou, Sheffield, UK.

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