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Longitudinally extensive transverse myelitis after Campylobacter jejuni enteritis
  1. Yudy Llamas1,
  2. Karl Hazel1,
  3. Patrick Nicholson2,
  4. Lisa Costelloe1
  1. 1Department of Neurology, Beaumont Hospital, Dublin, Ireland
  2. 2Department of Radiology, Beaumont Hospital, Dublin, Ireland
  1. Correspondence to Dr Yudy Llamas, Department of Neurology, Beaumont Hospital, Dublin 9, Ireland; yudyllamas{at}gmail.com

Abstract

Campylobacter jejuni infection is well-known to precipitate Guillain-Barré syndrome through an immune-mediated attack on the peripheral nervous system. Molecular mimicry between C. jejuni lipo-oligosaccharides on the surface of infectious agents and human gangliosides in the peripheral nerves induces cross-reactive immune responses. Although gangliosides also occur in the central nervous system (CNS), autoimmune CNS disorders rarely follow C. jejuni infections. However, longitudinally extensive transverse myelitis commonly has a parainfectious cause, triggered by a wide range of micro-organisms including viruses and bacteria. We report a patient who developed longitudinally extensive transverse myelitis after C. jejuni enteritis associated with antiganglioside antibodies.

  • campylobacter
  • ganglioside
  • myelopathy

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Footnotes

  • Contributors YL, conceptualisation and manuscript drafting, literature search, and analysis and interpretation of the case and underlying mechanisms. KH, manuscript drafting. PN, interpreted the MRI as well as contributed to the writing of the manuscript. LC, the patient’s attending neurologist, and contributed to study concept, drafting and interpretation of the case, and reviewed the manuscript.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Ethics Committee Beaumont Hospital.

  • Provenance and peer review Not commissioned. Externally peer reviewed. This paper was reviewed by Neil Robertson, Cardiff, UK.

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