Cerebral vasospasm and anterior circulation stroke secondary to an exacerbation of hereditary corproporphyria

Pract Neurol. 2012 Dec;12(6):384-7. doi: 10.1136/practneurol-2012-000288.

Abstract

Acute porphyria, though rare, has well-known neurological sequelae. Vasospasm rarely complicates exacerbations of acute intermittent porphyria, but has not been previously reported in hereditary coproporphyria. We describe a porphyric crisis in a woman with previously undiagnosed hereditary coproporphyria (triggered by rifampicin), leading to vasospasm and stroke.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain / diagnostic imaging
  • Brain / pathology
  • Coproporphyria, Hereditary / chemically induced
  • Coproporphyria, Hereditary / complications*
  • Coproporphyria, Hereditary / therapy
  • Female
  • Humans
  • Magnetic Resonance Angiography
  • Magnetic Resonance Imaging
  • Radiography
  • Rifampin / adverse effects
  • Stroke / diagnosis
  • Stroke / etiology*
  • Vasospasm, Intracranial / diagnosis
  • Vasospasm, Intracranial / etiology*

Substances

  • Rifampin