TY - JOUR T1 - Recovery from blindness following accidental quinine overdose JF - Practical Neurology JO - Pract Neurol DO - 10.1136/practneurol-2017-001610 SP - practneurol-2017-001610 AU - Hildegard Nikki Hall AU - Andrew J Tatham Y1 - 2017/08/04 UR - http://pn.bmj.com/content/early/2017/08/04/practneurol-2017-001610.abstract N2 - A 46-year-old woman presented with sudden loss of vision in both eyes, apparent since waking. She also complained of partial hearing loss. The previous evening she had experienced difficulty sleeping due to (long-standing) restless legs and had self-medicated with quinine, taking an accidental overdose of 1.8 g.On admission, she was alert but unable to perceive light in either eye, and had fixed, dilated pupils. Other than mild bilateral sensorineural hearing loss, the remainder of the neurological examination was normal. She was haemodynamically stable, but her ECG showed QT interval prolongation at 501 ms (normal 350–440); she therefore received intravenous sodium bicarbonate for suspected myocardial toxicity.Ophthalmological review that day confirmed a visual acuity of no light perception and a bilateral afferent pupillary defect. Fundal examination suggested mild retinal oedema. Given the profound visual loss, we prescribed a 4-week course of oral nimodipine 60 mg 4-hourly, … ER -