TY - JOUR T1 - Focal precentral gyrus involvement in osmotic demyelination JF - Practical Neurology JO - Pract Neurol DO - 10.1136/practneurol-2017-001682 SP - practneurol-2017-001682 AU - Martin R Turner AU - John Jacob AU - Lucy Matthews AU - Fintan Sheerin Y1 - 2017/08/17 UR - http://pn.bmj.com/content/early/2017/08/19/practneurol-2017-001682.abstract N2 - A previously well 59-year-old woman was admitted to a regional hospital with subacute encephalopathy and found to have severe hyponatraemia (101 mmol/L). She had taken indapamide for hypertension over the preceding 3 months. Before referral to neurological services, she had received intravenous hypertonic saline. Her serum sodium concentration normalised within a few days, but was associated with a deteriorating conscious level. She was referred to our tertiary neurological centre with suspected osmotic demyelination where she presented in a ‘locked in’ state, involving quadriplegia and absent vertical … ER -