TY - JOUR T1 - Lupus myelopathy JF - Practical Neurology JO - Pract Neurol DO - 10.1136/practneurol-2017-001756 SP - practneurol-2017-001756 AU - Dominika D Raciborska AU - Alastair John Noyce AU - Dev Pyne AU - Benjamin P Turner Y1 - 2017/11/02 UR - http://pn.bmj.com/content/early/2017/11/02/practneurol-2017-001756.abstract N2 - Although neurological manifestations of systemic lupus erythematosus (SLE) are well recognised, myelopathy complicating SLE is rare. A 35-year-old woman presented with non-specific symptoms and a respiratory tract infection but had serological evidence of SLE. She subsequently deteriorated rapidly, developing a catastrophic spinal cord syndrome. Her initial MRI was normal; but after 1 month, her encephalopathy having progressed, repeat imaging showed characteristic myelitic changes. She responded only slowly to a combination of cyclophosphamide and corticosteroids. This case exemplifies the mixed presentations of SLE, including the under-recognised ‘subpial leukomyelopathy’ of central nervous system lupus. It highlights the challenges in managing lupus-related myelopathy and the benefits of a multidisciplinary approach to care. ER -