|Seizures||Implies less likely to be CJD, infective and immune encephalitis, neoplasia, many other mimics|
|Facial movement disorder||NMDA-R encephalitis, CNS Whipple’s disease|
|Modest progression||Implies less likely to be CJD, more likely to be a common neurodegenerative disorder|
|CSF pleocytosis||Infections, lymphoma, inflammatory, neoplastic|
|Contrast-enhancing lesions||Infections, lymphoma, inflammatory, neoplastic|
|MRI hyperintensities on T2-weighted imaging outside the striatum, thalamus and cortex||Vascular diseases, lymphoma, progressive multifocal leukoencephalopathy, encephalitis, extrapontine myelinolysis, others|
CJD, Creutzfeldt–Jakob disease; CNS, central nervous system; CSF, cerebrospinal fluid; NMDA-R, N-methyl-D-aspartate; VGKC, voltage-gated potassium channel.