The control of oral secretions in bulbar ALS/MND
References (12)
Physiology and pathology of the mucociliary system
(1989)Biology of the salivary glands
(1993)
Cited by (75)
Using Intensity Modulated Radiation Therapy for the Treatment of Sialorrhea in Amyotrophic Lateral Sclerosis
2023, Advances in Radiation OncologyCitation Excerpt :First, we qualitatively and quantitatively measured the patient's baseline degree of sialorrhea. We used the Sialorrhea Scoring Scale (Table 1),5-8 which was developed for Parkinson's disease and validated for ALS, as well the Oral Secretion Scale (Table 2),9-12 which was designed specifically for sialorrhea in ALS. These scales are both simple rating tools in which patients report the severity of their sialorrhea symptoms.
Symptom Management and End-of-Life Care in Amyotrophic Lateral Sclerosis
2015, Neurologic ClinicsCitation Excerpt :Using a room humidifier for those not using noninvasive ventilation (NIV) and bleeding humidified air into the machine for those who do may reduce their tenacity. An open-label trial of 16 patients with thick secretions who had failed anticholinergic therapy and were treated with either propanolol 10 mg twice a day or metoprolol 25 mg twice a day found that 75% of patients reported decreased secretions, with sustained short-term efficacy in most.15 Drinking papaya or pineapple juice and reducing caffeine, milk, or alcohol have been anecdotally suggested.16
The Respiratory System and Neuromuscular Diseases
2015, Murray and Nadel's Textbook of Respiratory Medicine: Volume 1,2, Sixth EditionSalivary glands radiotherapy to reduce sialorrhea in amyotrophic lateral sclerosis: Dose and energy
2013, Cancer/RadiotherapieCitation Excerpt :This symptom can cause social and psychological problems and increases the risk of aspiration pneumonia. Different methods have been tested for alleviating drooling, including pharmacological treatments (anticholinergics, scopolamine, beta-blockers, tricyclic antidepressants, botulinum toxin) and various surgical procedures [1,4–6,8,9,11]. Alternatively, radiotherapy of the salivary glands has been tested when previous pharmacological treatments produced unsatisfactory results and/or side effects [10,12–15].
Rehabilitation of motor neuron disease
2013, Handbook of Clinical NeurologyCitation Excerpt :Levodopa (Udaka et al., 1984) and lithium (Shader, 1992) have been reported to be useful, while a combination of dextromethorphan hydrobromide and quinidine sulfate has demonstrated efficacy in a randomized controlled trial (Brooks et al., 2004). Secretions that require management in ALS are serous and mucus secretions from the salivary glands, and also mucus from the nose and lungs (Newall et al., 1996). Sialorrhea with associated drooling is related to salivary gland output.
The interaction between the nervous system and the stomatognathic system: from development to diseases
2023, International Journal of Oral Science