Multifocal necrotising leucoencephalopathy following Salmonella infection in an immunocompetent patient

Pract Neurol. 2018 Apr;18(2):156-158. doi: 10.1136/practneurol-2017-001664. Epub 2017 Sep 28.

Abstract

Multifocal necrotising leucoencephalopathy is a rare disorder affecting the central nervous system. It is characterised pathologically by microscopic areas of necrosis with pontine predilection but also involvement of extrapontine regions, including the cerebellum, medulla and cerebral hemispheres. It usually occurs on the background of immunosuppression. Here we describe an immunocompetent patient with a recent history of Salmonella infection who presented with subacute neurological deterioration. At postmortem, she had evidence of multifocal necrotising leucoencephalopathy.

Keywords: multifocal necrotizing leukoencephalopathy; salmonella.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Fatal Outcome
  • Female
  • Gastroenteritis / microbiology
  • Humans
  • Leukoencephalopathies / microbiology*
  • Leukoencephalopathies / pathology
  • Necrosis
  • Salmonella Infections / complications*