User profiles for "author:David K Simon"
 | David K. SimonBeth Israel Deaconess Medical Center and Harvard Medical School Verified email at bidmc.harvard.edu Cited by 12937 |
[PDF][PDF] Parkinson disease epidemiology, pathology, genetics, and pathophysiology
SYNOPSIS (1 paragraph): Parkinson's disease (PD) is a complex age-related
neurodegenerative disease associated with dopamine deficiency and both motor and …
neurodegenerative disease associated with dopamine deficiency and both motor and …
Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases
The gold standard for a definitive diagnosis of Parkinson disease (PD) is the pathologic
finding of aggregated α-synuclein into Lewy bodies and for Alzheimer disease (AD) …
finding of aggregated α-synuclein into Lewy bodies and for Alzheimer disease (AD) …
[HTML][HTML] Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
J St-Pierre, S Drori, M Uldry, JM Silvaggi, J Rhee… - Cell, 2006 - cell.com
PPARγ coactivator 1α (PGC-1α) is a potent stimulator of mitochondrial biogenesis and
respiration. Since the mitochondrial electron transport chain is the main producer of reactive …
respiration. Since the mitochondrial electron transport chain is the main producer of reactive …
[HTML][HTML] Trial of cinpanemab in early Parkinson's disease
AE Lang, AD Siderowf, EA Macklin… - … England Journal of …, 2022 - Mass Medical Soc
Background Aggregated α-synuclein plays an important role in Parkinson's disease
pathogenesis. Cinpanemab, a human-derived monoclonal antibody that binds to α …
pathogenesis. Cinpanemab, a human-derived monoclonal antibody that binds to α …
A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit
MF Beal, D Oakes, I Shoulson, C Henchcliffe… - JAMA …, 2014 - jamanetwork.com
Importance Coenzyme Q10 (CoQ10), an antioxidant that supports mitochondrial function,
has been shown in preclinical Parkinson disease (PD) models to reduce the loss of …
has been shown in preclinical Parkinson disease (PD) models to reduce the loss of …
High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain
MT Lin, DK Simon, CH Ahn, LM Kim… - Human molecular …, 2002 - academic.oup.com
The mitochondrial theory of aging proposes that mitochondrial DNA (mtDNA) accumulates
mutations with age, and that these mutations contribute to physiological decline in aging and …
mutations with age, and that these mutations contribute to physiological decline in aging and …
Meta‐analysis of Parkinson's Disease: Identification of a novel locus, RIT2
N Pankratz, GW Beecham, AL DeStefano… - Annals of …, 2012 - Wiley Online Library
Objective: Genome‐wide association (GWAS) methods have identified genes contributing to
Parkinson's disease (PD); we sought to identify additional genes associated with PD …
Parkinson's disease (PD); we sought to identify additional genes associated with PD …
Development of topographic order in the mammalian retinocollicular projection
DK Simon, DD O'leary - Journal of Neuroscience, 1992 - Soc Neuroscience
We have used the anterograde axon tracer 1, 1′-dioctodecyl-3, 3, 3′, 3′-
tetramethylindocarbocyanine perchlorate (Dil) to characterize the development of …
tetramethylindocarbocyanine perchlorate (Dil) to characterize the development of …
N-methyl-D-aspartate receptor antagonists disrupt the formation of a mammalian neural map.
DK Simon, GT Prusky, DD O'leary… - Proceedings of the …, 1992 - National Acad Sciences
The topographic ordering of retinal connections in the rat superior colliculus emerges during
early postnatal life from an initially diffuse projection. Disruption of N-methyl-D-aspartate …
early postnatal life from an initially diffuse projection. Disruption of N-methyl-D-aspartate …