The understanding of brain function is moving rapidly towards a systems-level, network-
based approach. It is now as naive to talk simplistically about what a particular area of the …

Advances in neuroimaging, complementing histopathological insights, have established a
multi-system involvement of cerebral networks beyond the traditional neuromuscular …

FIGURE 1.-This portrayal of the retail structure of the City of Philadelphia was determined
from analyses of block-frontage volume of sales. The statistical conclusions were checked in …

Objective To discern presymptomatic changes in brain structure or function using advanced
MRI in carriers of mutations predisposing to amyotrophic lateral sclerosis (ALS). Methods T1 …

The reduction in ALS Functional Rating Score (ALSFRS) from reported symptom onset to
diagnosis is used to estimate rate of disease progression. ALSFRS decline may be non …

Familial cases of frontotemporal dementia (FTD) provide an opportunity to study the
pathophysiology of this clinically diverse condition. The C9ORF72 mutation is the most …

A relative preservation of eye movements is notable in ALS, but saccadic functions have not
been studied longitudinally. ALS overlaps with FTD, typically involving executive …

Continuous rhythmic neuronal oscillations underpin local and regional cortical
communication. The impact of the motor system neurodegenerative syndrome amyotrophic …

Objectives The neural activity of the primary motor cortex is variably synchronised with
contralateral peripheral electromyographic signals, which is thought to facilitate long-range …

Objective We sought to assess cortical function in amyotrophic lateral sclerosis (ALS) using
noninvasive neural signal recording. Methods Resting-state magnetoencephalography was …