Article Text
PDF
Abstract
Paraneoplastic neurological syndromes can be associated with the presence of onconeural antibodies. These antibodies are the result of an immune response against a tumour that is ectopically expressing a neuronal antigen. The ‘classical’ onconeural antibodies (anti-Hu, Yo, Ma2, CRMP-5, amphiphysin and Ri) are directed against intracellular antigens and are strongly associated with underlying malignancy. By contrast, onconeural antibodies directed against cell surface antigens (eg, anti-NMDA, VGKC, AChR) have a weaker tumour association. This article gives a practical overview of the tumour associations, and the neurological associations, of the onconeural antibodies. There is also guidance on how to investigate occult malignancy in antibody positive cases.
Statistics from Altmetric.com
Read the full text or download the PDF:
Other content recommended for you
- Republished: Which antibody and which cancer in which paraneoplastic syndromes?
- Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition
- Paraneoplastic neurological syndromes: a practical approach to diagnosis and management
- Rhombencephalomyelitis due to possible paraneoplastic syndrome associated with Hodgkin’s lymphoma
- Opsoclonus-myoclonus paraneoplastic syndrome in nasopharyngeal carcinoma
- A rare case of long-term paraesthesia diagnosed as a paraneoplastic syndrome by anti-SOX1 antibody determination
- Recommended diagnostic criteria for paraneoplastic neurological syndromes
- Protein kinase Cγ autoimmunity in paraneoplastic cerebellar degeneration and non-small-cell lung cancer
- Delayed onset of a second paraneoplastic neurological syndrome in eight patients
- Anti-Yo paraneoplastic cerebellar degeneration in a patient with stage IV ovarian adenocarcinoma during bevacizumab maintenance therapy