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Histiocytosis for the neurologist: a case of Erdheim–Chester disease
  1. Johann R Selvarajah1,
  2. Mary Greta Rodrigues2,
  3. Sara Ali3
  1. 1Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK
  2. 2Department of Histopathology, Hull Royal Infirmary, Hull, UK
  3. 3Department of Haematology, Hull Royal Infirmary, Hull, UK
  1. Correspondence to Dr Johann R Selvarajah, Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK; Johann.Selvarajah{at}


The histiocytoses are a rare but diverse group of disorders, ranging from localised, self-limiting lesions to disseminated, fulminant, multi-system disease. Some histiocytoses may cause or present with neurological disease and their recognition can be challenging. We illustrate this with a case, followed by a discussion of the clinical characteristics and management of the more common histiocytoses that may present to the neurologist.

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