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Sudden proximal paraparesis secondary to statin myositis
  1. Julien Lagarde1,
  2. Corina Cret1,
  3. Dalia Dimitri2,
  4. Frédéric Klapczynski1,
  5. Alain Améri1
  1. 1Department of Neurology, Centre hospitalier de Meaux, Meaux cedex, France
  2. 2Centre de référence des maladies neuro-musculaires Garches-Necker-Mondor-Hendaye, AP-HP, Consultation des pathologies neuro-musculaires, Service d'histologie, INSERM U841, CHU Henri Mondor, Créteil, France
  1. Correspondence to Dr Corina Cret, Department of Neurology, Centre hospitalier de Meaux, 6-8 rue Saint-Fiacre, FR-77104 Meaux cedex, France; c-cret{at}

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Myotoxicity due to statin medication is a well-known entity. Statin myopathies usually evolve either subacutely or chronically.1 They are classically diffuse, affecting all four limbs mainly proximally; focal myositis is rare in this setting.2 ,3 We report an atypical case of statin myopathy predominantly involving the quadriceps muscles with an unexpectedly abrupt onset.

Case report

A 75-year-old man presented with sudden onset of bilateral proximal lower limb weakness. On trying to stand up after finishing dinner, he had fallen backwards without losing consciousness. He had great difficulty getting up again and lay on the floor for several hours before being able to call for help. He had never previously experienced muscle pain or weakness and had not performed any unusual exercise in the preceding days or hours. He had a history of hypertension, diabetes mellitus, myocardial infarction and coronary bypass surgery. He took atenolol, metformin, aspirin and rosuvastatin. He did not …

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  • Competing interests None.

  • Provenance and peer review Not commissioned; internally peer reviewed.

  • This paper was reviewed by Hadi Manji, London, UK.

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