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Methanol toxicity presenting as haemorrhagic putaminal necrosis and optic atrophy
  1. Prabhat Singh1,
  2. Vimal Kumar Paliwal1,
  3. Zafar Neyaz2,
  4. Vikas Kanaujia3
  1. 1 Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
  2. 2 Department of Radiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
  3. 3 Department of Neuro Ophthalmology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
  1. Correspondence to Dr Vimal Kumar Paliwal, Department of Neurology, SGPGIMS, Raebareli Road, Lucknow 226014, India; dr_vimalkpaliwal{at}

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A 27-year-old man developed acute headache, vomiting and abnormal behaviour for more than 3 days; on the third day, he developed bilateral visual loss, progressing over several hours to complete blindness. There was no fever and no history of seizures or trauma; he initially denied excessive or unusual alcohol consumption. He presented to us 1 month later for the evaluation of blindness. On examination, he had no light perception in either eye. His pupils were dilated and non-reacting, and fundoscopy showed bilateral optic atrophy (figure 1). Routine haematological and biochemical blood tests were normal. An MR scan of the brain showed bilateral haemorrhagic putaminal necrosis (figure 2). On direct questioning when alone, he described drinking local-made alcohol on the day of his illness. Initially, with his …

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  • Additional material is published online only. To view please visit the journal online (

  • Contributors VKP conceived and wrote the manuscript. PS, ZN, VK collected data and helped in editing and revising the manuscript.

  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned. Externally peer reviewed.

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