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Mesothelioma and anti-Ma paraneoplastic syndrome; heterogeneity in immunogenic tumours increases
  1. Hilary Anne Archer1,
  2. Aikaterini Panopoulou2,
  3. Nidhi Bhatt3,
  4. Anthony James Edey4,
  5. Nicola Jane Giffin2
  1. 1Department of Neurosciences, Frenchay Hospital, Bristol, UK
  2. 2Department of Neurology, Royal United Hospital Bath, Bath, UK
  3. 3Department of Histopathology, Bristol Royal Infirmary, Bristol, UK
  4. 4Department of Radiology, Southmead Hospital, Southmead Hospital, Bristol, UK
  1. Correspondence to Dr Hilary Archer, Department of Neurosciences, Frenchay Hospital, Frenchay Park Road, Bristol, UK, BS16 1LE; hilary.archer{at}


We present a patient with opsoclonus and diffuse cerebellar signs who had an anti-Ma2 antibody-associated paraneoplastic syndrome secondary to a sarcomatoid mesothelioma. This case highlights the importance of early tumour detection, instigation of therapeutic measures, and the heterogeneity of underlying malignancies in neurological paraneoplastic syndromes.

  • Cerebellar Disease
  • Neuroophthalmology
  • Paraneoplastic Syndrome

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