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Multiple sclerosis presenting as a relapsing amnestic syndrome
  1. Peter Owen Jenkins1,
  2. Richard Perry2,
  3. Omar Malik2
  1. 1Neurology Department, St Georges Healthcare NHS Trust, London, UK
  2. 2Neurosciences Department, Imperial Healthcare NHS Trust, London, UK
  1. Correspondence to Dr Omar Malik, Neurosciences Department, Imperial Healthcare NHS Trust, Third Floor, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK; omar.malik{at}

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Although neuropsychiatric symptoms are increasingly recognised in early established multiple sclerosis,1–3 it is unusual for patients to present with solitary cognitive or neuropsychiatric symptoms,4–12 including depressive symptoms4–7 ,10 ,11 and progressive cognitive decline.6 ,8 ,9 ,11 ,12 Here, we present a case of multiple sclerosis that presented as a relapsing amnestic syndrome with only very mild underlying cognitive changes.


A previously fit 76-year-old man reported a 2–3-h episode of agitation and confusion. During this, he became repetitive and obsessive and had no memory of this period afterwards. Following the event, his wife noticed that his memory was not quite as good as previously (particularly for people's names), but otherwise he had no residual cognitive or physical deficits.

His wife also reported that the year before …

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  • Contributors PJ was responsible for drafting the article and obtaining consent. RP and OM were responsible for critically revising the article. OM was responsible for conception of the article.

  • Competing interests None.

  • Provenance and peer review Not commissioned; internally peer reviewed.

  • Patient consent Obtained.

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