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Contributors JB, CK-M, PCB, S-HL-K, AO, IWT-L: conception and design, drafting, final approval.
Funding AO was supported by the National Institutes of Health/National Cancer Institute (Training Grant No.5T32CA163185).
Competing interests None declared.
Patient consent Obtained.
Ethics approval IRB.
Provenance and peer review Not commissioned; externally peer reviewed. This paper was reviewed by Simon Kerrigan, Bristol, UK.