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Curious turns in the night-time
  1. Angharad Davis1,2,
  2. Aidan Neligan2,3,
  3. Nazia Raja2,
  4. Andrew Kelso2
  1. 1Department of Neurosciences, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University, London, UK
  2. 2Department of Neurology, Barts Health NHS Trust, London, UK
  3. 3Department of Neurosciences, Homerton University Hospital NHS Trust, London, UK
  1. Correspondence to Dr Angharad Grace Davis, Department of Neurosciences, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University, London, UK; angharadgracedavis{at}

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A 63-year-old Caucasian man reported 1 year of sleep disturbance. He described waking repeatedly from sleep with feeling light-headed upon sitting up. He would then gasp for air, move his head from side to side, lose consciousness for a few seconds and recover immediately without confusion. He also had similar episodes during the daytime, although less frequently. He had frequently felt light-headed on standing for some time. He had been previously well apart from some situational vasovagal syncope as a teenager. He had a normal birth and early life, with normal developmental milestones. On examination, there was a postural drop in blood pressure from 120/90 mm Hg (lying) to 100/70 mm Hg (standing) after 3 min. Neurological and cardiology examinations were otherwise normal.

Question 1

What are the unusual features, and what is your initial diagnosis?


The main differential diagnoses are syncope and epilepsy. While the episodes were stereotyped, suggesting epilepsy, other features—such as the consistent prodrome of preceding light-headedness and previous vasovagal episodes—might suggest autonomic dysregulation, possibly with sleep parasomnia or cardiac syncope.

Misdiagnosing blackouts can increase mortality and morbidity: there are several well-recognised clinical markers that can help to differentiate seizures from syncope.

Question 2

What investigations would you perform, and how would you distinguish seizure from syncope?


Cardiac investigations, including 24-h ECG monitoring and echocardiogram were normal, as were an MR scan of brain and routine electroencephalogram (EEG). Subsequent video EEG telemetry recorded a total of 17 events during both sleep and wakefulness. At night, he would wake from sleep, panting uncontrollably …

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  • Contributors All authors have contributed to the care of the patient described in the case report. The manuscript was prepared by AGD and subsequently edited by AN, NR and AK. There are no relevant funding sources. There are no competing interests with relation to this manuscript.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed. This paper was reviewed by Paul Cooper, Manchester, UK.

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  • Editors' commentary
    Phil Smith Geraint N Fuller

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