Adult-onset Alexander's disease mimicking degenerative disease
Adult-onset Alexander's disease is a rare leukodystrophy that can present later in life in a variety of ways, often mimicking more common neurodegenerative conditions. We present two cases with novel mutations, diagnosed from their characteristic MR scan findings. Even in much older people, clinicians should have a high clinical suspicion if there are typical imaging findings.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Read the full text or download the PDF:
Other content recommended for you
- A novel mutation in the GFAP gene expands the phenotype of Alexander disease
- The clinicopathological spectrum of Rosenthal fibre encephalopathy and Alexander’s disease: a case report and review of the literature
- Republished: A practical approach to late-onset cerebellar ataxia: putting the disorder with lack of order into order
- A practical approach to late-onset cerebellar ataxia: putting the disorder with lack of order into order
- A practical approach to diagnosing adult onset leukodystrophies
- Spinal cord involvement in adult-onset metabolic and genetic diseases
- Respiratory difficulty with palatal, laryngeal and respiratory muscle tremor in adult-onset Alexander’s disease
- Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia
- ADULT ONSET ALEXANDER DISEASE: A DIAGNOSIS TO CONSIDER IN LATE–ONSET SPORADIC SPINOCEREBELLAR ATAXIA
- Different neuroinflammatory profile in amyotrophic lateral sclerosis and frontotemporal dementia is linked to the clinical phase