Footnotes

• Contributors AM acquired the clinical data and wrote the manuscript. ZM wrote the manuscript and revised the manuscript for critical content. MT interpreted histology, created figure and revised the manuscript for critical content. CC, DC and CM acquired the clinical data and revised the manuscript for critical content.

• Funding AM reports that she has received salary funding from the Health Service Executive (HSE)/Dr Richard Steeven's scholarship and UCC Ainsworth prize. This work was supported by the NIHR Queen Square Dementia Biomedical Research Unit and was performed at UCLH which receives funding in part from the Department of Health NIHR Biomedical Research Centre.

• Competing interests None declared.

• Patient consent Obtained.

• Provenance and peer review Not commissioned; externally peer reviewed. This paper was reviewed by Nick Davies, London, UK.