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Headache management: pharmacological approaches
  1. Alex J Sinclair1,2,
  2. Aaron Sturrock2,
  3. Brendan Davies3,
  4. Manjit Matharu4
  1. 1Department of Neurobiology, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, UK
  2. 2Neurology Department, University Hospitals Birmingham NHS Trust, Queen Elizabeth Hospital Birmingham, Birmingham, UK
  3. 3Department of Neurology, Royal Stoke University Hospital, Stoke-on-Trent, UK
  4. 4Headache Group, Institute of Neurology, London, UK
  1. Correspondence to Dr Alex J Sinclair, Department of Neurobiology, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, The Medical School, The University of Birmingham, Wolfson Drive, Edgbaston, Birmingham B15 2TT, UK; a.b.sinclair{at}


Headache is one of the most common conditions presenting to the neurology clinic, yet a significant proportion of these patients are unsatisfied by their clinic experience. Headache can be extremely disabling; effective treatment is not only essential for patients but is rewarding for the physician. In this first of two parts review of headache, we provide an overview of headache management, emerging therapeutic strategies and an accessible interpretation of clinical guidelines to assist the busy neurologist.


This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See:

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