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Contemporary management of low-­grade glioma: a paradigm shift in neuro-oncology
  1. Caroline Hayhurst
  1. Department of Neurosurgery, University Hospital of Wales, Cardiff, UK
  1. Correspondence to Caroline Hayhurst, Department of Neurosurgery, University Hospital of Wales, Cardiff CF14 4XW, UK; carolinehayhurst{at}


Supratentorial diffuse intrinsic low-grade gliomas represent a distinct but heterogenous group of tumours, with the propensity to grow and to differentiate into malignant tumours. They have been historically viewed in the ‘benign’ spectrum of intrinsic brain tumours, so a watch-and-wait policy was often adopted. With recent advances in our understanding of the natural history of these tumours, combined with advances in surgical technique, an aggressive approach is now recommended. Increasing quality evidence of the impact of tumour resection and multicentre trials of adjuvant radiotherapy and chemotherapy have led to a new algorithm for low-grade glioma management. This review aims to outline the emerging evidence that has shifted neuro-oncology practice.

  • low-grade glioma
  • awake craniotomy
  • molecular genetics
  • survival

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  • Contributors I have solely devised and written the manuscript.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; externally peer reviewed. This paper was reviewed by Fiona McKevitt, Sheffield, UK.

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  • Editors’ commentary
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