We present a case of cerebellar dysfunction due to severe hypothyroidism induced by pembrolizumab, a member of the ‘immune checkpoint inhibitor’ class of cancer immunotherapies. Thyroxine replacement completely resolved his symptoms and signs. We also discuss the neurological immune-related complications of checkpoint inhibitors.
- cerebellar ataxia
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Contributors AB drafted this case report. CM and AJC edited the report and contributed to the discussion.
Competing interests None declared.
Patient consent Obtained.
Provenance and peer review Not commissioned; externally peer reviewed. This paper was reviewed by Marios Hadjivassiliou, Sheffield, UK.
Correction notice This article has been corrected since it was published Online First. The affiliations numbered 2 and 3 have been switched around.