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Contributors SQ: study concept and design, acquisition, analysis and interpretation of data. JD-GS: acquisition of data, revision of manuscript. CA-C: genetic analysis, revision of manuscript. MTC: analysis and interpretation of data, revision of manuscript, study supervision.
Competing interests None declared.
Patient consent Obtained.
Provenance and peer review Not commissioned; externally peer reviewed. This paper was reviewed by William Whiteley, Edinburgh, UK.