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Multifocal necrotising leucoencephalopathy following Salmonella infection in an immunocompetent patient
  1. Michael A O’Gara1,
  2. Sonali Dharia1,
  3. David Hilton2,
  4. Nicholas J Gutowski1
  1. 1 Department of Neurology, Royal Devon and Exeter Hospital, Exeter, UK
  2. 2 Department of Neuropathology, Derriford Hospital, Plymouth, UK
  1. Correspondence to Dr Michael A O’Gara, Department of Neurology, Royal Devon & Exeter Hospital, Exeter, Devon EX2 5DW, UK; michaelogara{at}


Multifocal necrotising leucoencephalopathy is a rare disorder affecting the central nervous system. It is characterised pathologically by microscopic areas of necrosis with pontine predilection but also involvement of extrapontine regions, including the cerebellum, medulla and cerebral hemispheres. It usually occurs on the background of immunosuppression. Here we describe an immunocompetent patient with a recent history of Salmonella infection who presented with subacute neurological deterioration. At postmortem, she had evidence of multifocal necrotising leucoencephalopathy.

  • multifocal necrotizing leukoencephalopathy
  • salmonella

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  • Contributors MAO’G: completed the case report. SD: contributed to the drafting and assembling of information. NJG: contributed to the drafting. DH: contributed to the drafting.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed. This paper was reviewed by Alastair Wilkins, Bristol, UK.

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