A young woman presented with primary amenorrhoea, progressive haemiparesis, visual disturbance, dementia and focal motor seizures. Investigations showed hypopituitarism, unilateral cerebral atrophy and inflamed cerebrospinal fluid. A trans-sphenoidal biopsy gave a unifying diagnosis of a pituitary germinoma.
- paediatric neurology
- paediatric neuropathology
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BF and MN contributed equally.
Contributors BFG, MNPS: background research. BJAPB, MNPS: clinical data collection. FPF: pathological specimen analysis and manuscript draft. LTL: revision of CT/MRI findings for the case report and manuscript revision. CRO: revision of nuclear imaging findings for the case report and manuscript revision. LHMC, MNPS, BJAPB, MMS: participated in patient care. RN, BFG, MNPS, BJAPB, LHMC: manuscript draft/revision. MMS: conceptualised and revised the manuscript.
Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent Guardian consent obtained.
Provenance and peer review Not commissioned; externally peer reviewed. This paper was reviewed by Jeremy Rees, London, UK.