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Contributors All authors contributed equally to the manuscript. Conception and drafting of manuscript, final approval of revised submission and agreement to be accountable for all aspects of the work.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent Obtained.
Provenance and peer review Not commissioned. Externally peer reviewed by Nick Kane, Bristol, UK.