Article Text

Download PDFPDF
Multifocal Motor Neuropathy
  1. Hugh Willison*,
  2. Kerry Mills
  1. *University Department of Neurology, Southern General Hospital, Glasgow, UK, Email: h.j.willison{at};
  2. Academic Neuroscience Centre, King’s College Hospital, London, UK



During the 1980s, patients were reported with a slowly evolving asymmetrical motor syndrome, often initially affecting the distal upper limbs. These patients were viewed as distinct from either spinal muscular atrophy or more typical chronic inflammatory neuropathies by the presence on clinical electrophysiological testing of very focal areas of conduction block in the motor fibres of peripheral nerves, with sparing of sensory fibres in the same nerve segments. It was subsequently demonstrated, first of all in case reports and then in larger series of patients, that a proportion of these cases had serum IgM antibodies to GM1 ganglioside. Thus the syndrome of multifocal motor neuropathy with conduction block (MMN) was born. Since then, the literature on this uncommon disease has grown considerably, particular highlights being its frequent and dramatic response to infusions with intravenous immunoglobulin (IVIg), its pathophysiological basis, and its nosological relationship with similar clinical syndromes (Nobile-Orazio 2001).

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Other content recommended for you